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Spinal muscular atrophy
Strongest human evidence The METAOD006 (OPTIONS) Phase 2b trial randomized 502 adults with obesity (BMI 30-45 kg/m^2) to oral AOD-9604 (0.25, 0.5, or 1 mg/day) or placebo for 24 weeks alongside a supervised diet and exercise program
It causes sudden flares of intense pain in joints along with swelling, redness, and heat
Chatzifrangkeskou, M
In vitro studies demonstrate its role in modulating inflammatory gene expression profiles
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